Document 0192
 DOCN  M94A0192
 TI    Use of antineutrophil cytoplasmic autoantibodies in diagnosing
       vasculitis in a Chinese patient population.
 DT    9412
 AU    Li PK; Leung JC; Lai FM; Wang A; Lui SF; Leung CB; Lai KN; Department of
       Medicine, Chinese University of Hong Kong, Prince; of Wales Hospital,
       Shatin.
 SO    Am J Nephrol. 1994;14(2):99-105. Unique Identifier : AIDSLINE
       MED/94361175
 AB    Antineutrophil cytoplasmic autoantibodies (ANCA) have been used as
       markers of systemic vasculitides, including microscopic polyarteritis
       (MPA) and Wegener's granulomatosis. The diagnostic potential of ANCA
       assays together with antibodies against the neutrophil enzymes
       myeloperoxidase (MPO) and proteinase 3 for detecting a systemic
       vasculitis was tested in a Chinese patient population. 672 sera were
       received for ANCA assay, and ANCA detected by indirect
       immunofluorescence was positive in 73 sera from 42 patients. Of the 42
       patients, 3 had cytoplasmic ANCA, while 39 had a perinuclear pattern.
       There was no patient with Wegener's granulomatosis. Two cytoplasmic ANCA
       positive patients suffered from ulcerative colitis. Another cytoplasmic
       ANCA positive patient was a carrier of human immunodeficiency virus. Of
       the 39 perinuclear ANCA positive patients, 10 had MPA. Eight of them
       were tested for anti-MPO antibody, and all were positive. Other immune
       disorders that were perinuclear ANCA positive included: 13 patients with
       systemic lupus erythematosus, 3 with mixed connective tissue disease, 1
       with Goodpasture's syndrome, 2 with inflammatory bowel disease, and 2
       patients with IgA nephropathy. Anti-MPO antibody was not specific for
       MPA, and 7 out of the 13 patients with systemic lupus erythematosus were
       anti-MPO antibody positive. Our study suggests that ANCA and anti-MPO
       antibody are not specific for MPA in a Chinese population. They would
       alert the clinician of the possibility of vasculitis, but a
       clinicopathological correlation is essential in making the diagnosis.
 DE    Adolescence  Adult  Aged  Autoantibodies/BLOOD/*IMMUNOLOGY  Biological
       Markers/BLOOD  China  Colitis, Ulcerative/BLOOD/DIAGNOSIS/IMMUNOLOGY
       Cytoplasm/IMMUNOLOGY  Female  Fluorescent Antibody Technique
       Glomerulonephritis, IGA/BLOOD/DIAGNOSIS/IMMUNOLOGY  Goodpasture's
       Syndrome/BLOOD/DIAGNOSIS/IMMUNOLOGY  Human  HIV
       Infections/BLOOD/DIAGNOSIS/IMMUNOLOGY  Inflammatory Bowel
       Diseases/BLOOD/DIAGNOSIS/IMMUNOLOGY  Lupus Erythematosus,
       Systemic/BLOOD/DIAGNOSIS/IMMUNOLOGY  Male  Middle Age  Mixed Connective
       Tissue Disease/BLOOD/DIAGNOSIS/IMMUNOLOGY
       Neutrophils/ENZYMOLOGY/IMMUNOLOGY  Periarteritis
       Nodosa/BLOOD/DIAGNOSIS/IMMUNOLOGY  Peroxidase/METABOLISM  Predictive
       Value of Tests  Serine Proteinases/METABOLISM  Support, Non-U.S. Gov't
       Vasculitis/BLOOD/*DIAGNOSIS/ETHNOLOGY/IMMUNOLOGY  Wegener's
       Granulomatosis/BLOOD/DIAGNOSIS/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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